Fig. 6
From: System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis
Illustrative diagram showing the identified inflammatory molecular mechanisms of VCAM1 in EC during Gram-negative induced sepsis. VCAM1 in EC contains disease-specific phosphorylations at Tyr113 and Ser114 in pro-inflammatory processes of Gram-negative-induced sepsis. Additionally, the protein is actively degraded at Phe25, which might indicate resilience of EC during systemic pro-inflammatory processes affecting the vasculature