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Table 1 Phosphorylated proteins identified exclusively in Gram-negative sepsis in EC proteome. *Information about domains and structure for every protein was obtained from Uniprot. Numbers in brackets indicate the localization of the protein regions referred based on the amino acids’ position in the protein sequence

From: System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis

Gene symbol

Protein name

Modified residue

Post-translationally modified region*

Sptb

Spectrin beta chain erythrocytic

S1061, S1078, S2323

–

Cp

Ceruloplasmin

T83

Chain (20–1061), F5/8 type A 1 Domain (20–356), Plastocyanin-like 1 (20–199)

Hp

Haptoglobin

S210, S239

Polypeptide chain (19–347), Peptidase S1 domain (103–345)

Ckm

Creatine kinase M-type

T208, S224

Phosphagen kinase C-terminal domain (125–367)

Nsfl1c

Isoform 3 of NSFL1 cofactor p47

T108, S116

Before and after the nuclear localization signal motif (109–115)

Serpina1d

Alpha-1-antitrypsin 1–4

S300

Alpha-1-antitrypsin 1–4 Chain (25–413)

Vcam1

Vascular cell adhesion protein 1

Y113, S114

Extracellular domain (25–698)—next to I-set domain (C-terminal)