Fig. 10
From: Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome
Paxillin regulates ATP-induced activation of P2X7R receptor and NLRP3 inflammasome by formatting the P2X7R-Paxillin-NLRP3 complex. In the quiescent condition, the inactive, Paxillin and USP13 distribute in the cytoplasm (left). However, in response to extracellular ATP, Paxillin is a molecular adaptor protein, which recruits usp13 and NLRP3 at the plasma membrane for the activation of the NLRP3 inflammasome for efficient processing of P2X7R (right)