Table 4 Comparison of cancer driver variant predictors on the DRGN benchmark, with weighting of the predictions of the variants on each gene in function of the likelihood of Gi to host predominantly positive or negative samples. The last column shows the AUC drop with respect the EXPDRV+ALL data set in Table 2
Method | AUC | AUPRC | AUC drop |
|---|---|---|---|
ParsSNP | 52.9 | 52.3 | 34.0 |
CanDrA v+ | 51.7 | 52.1 | 35.4 |
Chasm 3.1 | 64.5 | 61.4 | 26.6 |
CHASMplus | 59.2 | 57.9 | 35.1 |
TransFIC | 57.5 | 54.8 | 10.5 |
FATHMM Cancer | 57.6 | 54.7 | 33.4 |
DummyLogOdd | 50.0 | 50.0 | 48.1 |