TY - JOUR AU - Baeumers, Miriam AU - Ruhnau, Kristina AU - Breuer, Thomas AU - Pannen, Hendrik AU - Goerlich, Bastian AU - Kniebel, Anna AU - Haensch, Sebastian AU - Weidtkamp-Peters, Stefanie AU - Schmitt, Lutz AU - Klein, Thomas PY - 2020 DA - 2020/12/22 TI - Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery JO - BMC Biology SP - 200 VL - 18 IS - 1 AB - A major task of the endosomal sorting complex required for transport (ESCRT) machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of maturing endosomes (MEs), which is essential for the complete degradation of transmembrane proteins in the lysosome. The ESCRT machinery is also required for the termination of signalling through activated signalling receptors, as it separates their intracellular domains from the cytosol. At the heart of the machinery lies the ESCRT-III complex, which is required for an increasing number of processes where membrane regions are abscised away from the cytosol. The core of ESCRT-III, comprising four members of the CHMP protein family, organises the assembly of a homopolymer of CHMP4, Shrub in Drosophila, that is essential for abscission. We and others identified the tumour-suppressor lethal (2) giant discs (Lgd)/CC2D1 as a physical interactor of Shrub/CHMP4 in Drosophila and mammals, respectively. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-020-00933-x DO - 10.1186/s12915-020-00933-x ID - Baeumers2020 ER -