Fig. 6
From: Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4
Oxidative stress targeting peripheral TRPA1 and central TRPV4 mediates thalidomide-induced mechanical allodynia. a–c Mechanical allodynia at day 7 following thalidomide (Thal, 50 mg/kg) or Veh and after the administration of i.pl. or a combination of i.pl. and i.th. phenyl-α-tert-butyl nitrone (PBN, 100 μg) or Veh. d Cold allodynia at day 7 following Thal (50 mg/kg, i.p.) or Veh and after the administration of i.pl. PBN (100 μg) or Veh. e, f Mechanical allodynia in Trpv4+/+, Trpv4−/−, Trpa1+/+, and Trpa1−/− mice at day 7 following Thal (50 mg/kg, i.p.) or Veh and after the administration of i.th. PBN (100 μg) or Veh. Data are mean ± SEM, n = 6 mice. *P < 0.05 vs. Veh Thal/Veh PBN; §P < 0.05 vs. Thal/Veh PBN; #P < 0.05 vs. Trpa1−/−/Thal/Veh PBN. Two-way ANOVA followed by Bonferroni’s post hoc test