TY - JOUR AU - Pluhackova, Kristyna AU - Horner, Andreas PY - 2021 DA - 2021/01/13 TI - Native-like membrane models of E. coli polar lipid extract shed light on the importance of lipid composition complexity JO - BMC Biology SP - 4 VL - 19 IS - 1 AB - Lipid-protein interactions stabilize protein oligomers, shape their structure, and modulate their function. Whereas in vitro experiments already account for the functional importance of lipids by using natural lipid extracts, in silico methods lack behind by embedding proteins in single component lipid bilayers. However, to accurately complement in vitro experiments with molecular details at very high spatio-temporal resolution, molecular dynamics simulations have to be performed in natural(-like) lipid environments. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-020-00936-8 DO - 10.1186/s12915-020-00936-8 ID - Pluhackova2021 ER -