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Table 1 Comparison of subunits in human (Hsa) and A. godoyi (Ago) ETC Complex I

From: The draft nuclear genome sequence and predicted mitochondrial proteome of Andalucia godoyi, a protist with the most gene-rich and bacteria-like mitochondrial genome

Core subunits “Eukaryote-specific subunits” “Metazoan-specific subunits”
Hsa Ago Hsa Ago Hsa Ago
MT-ND1 Nad1 NDUFAB1 SDAP NDUFA3 B9
MT-ND2 Nad2 NDUFA1 MWFE NDUFA7 B14.5a
MT-ND3 Nad3 NDUFA2 B8 NDUFA10 CI-42k
MT-ND4 Nad4 NDUFA5 B13 NDUFB1 n.d.
MT-ND4L Nad4L NDUFA6 B14 NDUFB2 AGGG
MT-ND5 Nad5 NDUFA8 PGIV NDUFB4 B15
MT-ND6 Nad6 NDUFA9 CI-39ka NDUFB5 n.d.
NDUFS2 Nad7 NDUFA11 B14.7 NDUFB6 n.d.
NDUFS8 Nad8 NDUFA13 B16.6 NDUFB8 ASHI
NDUFS3 Nad9 NDUFB3 B12 NDUFC1 n.d.
NDUFS7 Nad10 NDUFB7 B18 NDUFC2 B14.5b
NDUFS1 Nad11 NDUFB9 B22 NDUFV3 n.d.
NDUFV1 CI-51k NDUFB10 PDSW n.d. NUXMb
NDUFV2 CI-24k NDUFB11 ESSS n.d. NUUMb
NDUFA12 B17.2 NDUFS5 CI-15k   
NDUFS4 AQDQ     
NDUFS6 CI-13kA     
  1. Subunits shown in bold are encoded in mtDNA. n.d., not detected. A. godoyi nomenclature is based on that of bovine CI [44]
  2. aWe identified two distinct isoforms of this subunit in Andalucia, encoded by separate genes
  3. bNUXM and NUUM (identified in fungi) were initially considered to be distant homologs of the human subunits NDUFB1 and NDUFC1, respectively [48], but more recently this conclusion has been disputed [49]