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Table 1 Comparison of subunits in human (Hsa) and A. godoyi (Ago) ETC Complex I

From: The draft nuclear genome sequence and predicted mitochondrial proteome of Andalucia godoyi, a protist with the most gene-rich and bacteria-like mitochondrial genome

Core subunits“Eukaryote-specific subunits”“Metazoan-specific subunits”
HsaAgoHsaAgoHsaAgo
MT-ND1Nad1NDUFAB1SDAPNDUFA3B9
MT-ND2Nad2NDUFA1MWFENDUFA7B14.5a
MT-ND3Nad3NDUFA2B8NDUFA10CI-42k
MT-ND4Nad4NDUFA5B13NDUFB1n.d.
MT-ND4LNad4LNDUFA6B14NDUFB2AGGG
MT-ND5Nad5NDUFA8PGIVNDUFB4B15
MT-ND6Nad6NDUFA9CI-39kaNDUFB5n.d.
NDUFS2Nad7NDUFA11B14.7NDUFB6n.d.
NDUFS8Nad8NDUFA13B16.6NDUFB8ASHI
NDUFS3Nad9NDUFB3B12NDUFC1n.d.
NDUFS7Nad10NDUFB7B18NDUFC2B14.5b
NDUFS1Nad11NDUFB9B22NDUFV3n.d.
NDUFV1CI-51kNDUFB10PDSWn.d.NUXMb
NDUFV2CI-24kNDUFB11ESSSn.d.NUUMb
NDUFA12B17.2NDUFS5CI-15k  
NDUFS4AQDQ    
NDUFS6CI-13kA    
  1. Subunits shown in bold are encoded in mtDNA. n.d., not detected. A. godoyi nomenclature is based on that of bovine CI [44]
  2. aWe identified two distinct isoforms of this subunit in Andalucia, encoded by separate genes
  3. bNUXM and NUUM (identified in fungi) were initially considered to be distant homologs of the human subunits NDUFB1 and NDUFC1, respectively [48], but more recently this conclusion has been disputed [49]
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