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Fig. 5 | BMC Biology

Fig. 5

From: Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

Fig. 5

ADAR protein expression rescues the autophagy-related phenotype in Adar5G1 larval fat cells. The fat bodies of ac wild-type strain w1118, dfAdar5G1;CgIV>, and giAdar5G1;CgIV>UAS-Adar3/4 have been dissected and live-stained with DAPI (a, d, g) and Lysotracker (b, e, h) dyes (merges in c, f, i). Wild-type fat body does not show any Lysotracker staining (b, c). Adar5G1 mutant fat cells have an increased activation of autophagy as indicated by increased Lysotracker staining in lysosomes (e, f). Expression of the UAS-Adar3/4 transgene in the Adar5G1 mutant fat cells is sufficient to rescue the elevated basal autophagy (h, i). Scale bars, 50 μm

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