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Fig. 1 | BMC Biology

Fig. 1

From: Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells

Fig. 1

Hypomethylated mESC show aberrant H3K27me3 distribution. a Genome-wide volcano plot over 1-kb tiles showing redistribution of H3K27me3 in TKO mESC (n = 1). b Histograms of RRBS DNA methylation in parental wild-type mESC (n = 1) for the indicated H3K27me3 1-kb tiles. c Upper: scatter plots of parental wild-type mESC DNA methylation versus log2 fold changes in H3K27me3 for high and low CpG density 1-kb tiles. Lower: scatter plots of differential DNA methylation versus log2 fold changes in H3K27me3 for high and low CpG density 1-kb tiles. d Browser images of representative H3K27me3 gain (upper) and H3K27me3 (loss) regions, Titin and Foxo3 genes respectively. e RNAseq data in wild-type and TKO ES cells (n = 3) showing no major changes in core Polycomb component transcripts Ezh2, Eed and Suz12. See Additional file Table S3 for replicate metrics

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