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Fig. 3 | BMC Biology

Fig. 3

From: Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells

Fig. 3

HiBiv chromatin compaction is controlled by DNA methylation and PRC1. a Average plots of DNA methylation (WGBS, n = 1) in wild-type mESC across gene promoters defined as hiBiv and loBiv. b DNaseI-seq (n = 2) heatmap over clusters hiBiv and loBiv. Bottom: average profiles of heatmap data. c Averaged interaction ‘pileups’ between hiBiv and loBiv in Hi-C data (n = 2) from serum and 2i cultured cells. Value of the centre pixel is shown in the bottom left corner of each heatmap. Pixel scale on right. d Averaged interaction ‘pileups’ between hiBiv and loBiv in Hi-C data from wild-type (n = 4), RING1B I53A (n = 2) and RING1B KO (n = 2) cells. Value of the centre pixel is shown in the bottom left corner of each heatmap. Pixel scale on right. See Additional file Table S3 for replicate metrics

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