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Fig. 4 | BMC Biology

Fig. 4

From: Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells

Fig. 4

Developmental dynamics of Polycomb and DNA methylation. a, b ChIPseq heatmap profiles for H3K27me3 (red) and H3K4me3 (green) in oocyte, early mouse cleavage developmental stages and mESC (serum and 2i conditions). Bottom: average profiles of heatmap data. H3K27me3 replicates: oocyte (n = 3), 2 cell (n = 3), 4 cell (n = 3), 8 cell (n = 3), morula (n = 3), ICM (n = 2), ESC serum [4] and ESC-2i (n = 1). H3K4me3 replicates: oocyte (n = 4), 2 cell (n = 3), 4 cell (n = 3), 8 cell (n = 3), morula (n = 3), ICM (n = 2), ESC serum [2] and ESC-2i (n = 1). c Violin plots of WGBS DNA methylation levels, adjacent to TSS, in the indicated samples for hiBiv and loBiv. d Violin plots of WGBS DNA methylation levels, at CGI shores, in the indicated samples for hiBiv and loBiv. e Violin plots of WGBS DNA methylation levels at repetitive sequences in the indicated samples for hiBiv and loBiv. Replicates (ce): oocyte (n = 6), 2 cell (n = 9), 4 cell (n = 9) and ICM (n = 5). See Additional file Table S3 for replicate metrics

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