TY - JOUR AU - Penkov, Sider AU - Raghuraman, Bharath Kumar AU - Erkut, Cihan AU - Oertel, Jana AU - Galli, Roberta AU - Ackerman, Eduardo Jacobo Miranda AU - Vorkel, Daniela AU - Verbavatz, Jean-Marc AU - Koch, Edmund AU - Fahmy, Karim AU - Shevchenko, Andrej AU - Kurzchalia, Teymuras V. PY - 2020 DA - 2020/03/18 TI - A metabolic switch regulates the transition between growth and diapause in C. elegans JO - BMC Biology SP - 31 VL - 18 IS - 1 AB - Metabolic activity alternates between high and low states during different stages of an organism’s life cycle. During the transition from growth to quiescence, a major metabolic shift often occurs from oxidative phosphorylation to glycolysis and gluconeogenesis. We use the entry of Caenorhabditis elegans into the dauer larval stage, a developmentally arrested stage formed in response to harsh environmental conditions, as a model to study the global metabolic changes and underlying molecular mechanisms associated with growth to quiescence transition. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-020-0760-3 DO - 10.1186/s12915-020-0760-3 ID - Penkov2020 ER -