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Fig. 2 | BMC Biology

Fig. 2

From: Performance analysis of novel toxin-antidote CRISPR gene drive systems

Fig. 2

TARE drive. a In the TARE drive, germline activity disrupts the target gene, followed by embryo activity in the progeny of drive-carrying females. The target gene is assumed to be essential and haplosufficient, so any individuals inheriting two disrupted (recessive lethal) target genes are nonviable. By contrast, all individuals with at least one wild-type or drive allele are assumed to be viable. b The speed at which a TARE drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. The dashed line indicates the introduction frequency threshold in the deterministic model. c Same as b, but with varying germline and embryo cleavage rates. Gray means that the drive failed to reach 99% because it spread too slowly or was not able to spread at all

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