Fig. 5

TADDE drive. a In the TADDE drive, germline activity disrupts the target gene, and embryo activity is optional (and preferred unless germline cleavage is 100%). The target gene is haplolethal, so any individuals inheriting at least one disrupted target allele are nonviable unless they also inherit a drive allele, which encodes two copies of the gene or provides sufficient expression of the target gene such that only one copy is needed for rescue. b The speed at which the TADDE drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. The dashed line indicates the introduction frequency threshold in the deterministic model. c Same as b, but with varying germline and embryo cleavage rate