Fig. 6

TADS drive. a In the TADS drive, germline activity disrupts the target gene, followed by embryo activity in the progeny of drive-carrying females. The target gene is expressed in male gametocytes after meiosis I, and such expression is necessary for development of a viable sperm. Thus, sperm with a disrupted allele are nonviable, and only sperm with a wild-type or drive allele are viable. b The speed at which the TADS drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. c Same as b, but with varying germline and embryo cleavage rate