Fig. 7

TADS suppression drive. a The TADS suppression drive is distant-site, located in a male fertility gene and modeled here with a target gene that is unlinked from the drive allele. Male drive homozygotes are thus sterile (“drive homozygote fitness” does not apply). Germline activity disrupts the target gene, followed by embryo activity in the progeny of drive-carrying females. The target gene is expressed in male gametocytes after meiosis I, and such expression is necessary for the development of a viable sperm. Thus, sperm with a disrupted target allele are nonviable unless they also have a drive allele. b The speed at which the TADS suppression drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. Full suppression would occur within a few generations of this point. c Same as b, but with varying germline and embryo cleavage rate