Fig. 8

TADS Y-linked suppression drive. a The TADS Y-linked suppression drive is distant-site. It is located on the Y chromosome and has a target gene that is not linked to the drive allele (modeled here to be on an autosomal chromosome). Germline activity disrupts the target gene, followed by embryo activity in the progeny of drive-carrying females. The target gene has expression in male gametocytes after meiosis I, and such expression is necessary for development of a viable sperm. Thus, sperm with a disrupted target allele are nonviable unless they also have a drive allele. b The ability of the TADS Y-linked suppression drive to suppress a population in our deterministic model. If the germline cleavage rate is 100%, suppression will occur. Otherwise, suppression will occur only if the genetic load can overcome the fitness advantage of individuals at low population density. c The speed at which the TADS suppression drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. Full suppression or an equilibrium state will be attained within a few generations of this point. d Same as c, but with varying germline cleavage rate (the Y-linked drive can only be carried by males, so there would likely not be any embryo cleavage—however, if there was paternal activity due to unusually high nuclease/gRNA expression or stability, this would be expected to further increase drive efficiency)