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Table 1 Comparison of drive types. Blue represents high speed, potential for confinement, potential to use additional proter types, potential to avoid resistance, and ease of engineering, while yellow and red represent intermediate and low levels of these attributes

From: Performance analysis of novel toxin-antidote CRISPR gene drive systems

  1. *Thresholds assume a small fitness cost for the drive. Threshold is an indirect measure for the degree of confinement. Zero-threshold drives will potentially spread with even small migration levels, low and medium levels of confinement will constitute regional drives (possibly local for larger fitness costs), and high threshold systems should remain in a local area, if they are able to successfully persist [46]
  2. **A 2-locus 2-toxin-antitoxin (2L2T) underdominance [45, 46, 52] design with two TARE-like alleles [53]
  3. #The speed of a TADS drive is reduced if target species females mate multiple times and sperm from different males compete to fertilize eggs
  4. ##Moderate for formation of resistance, but effects of resistance have a more drastic impact for suppression drives than other types of drives
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BMC Biology

ISSN: 1741-7007

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