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Fig. 3. | BMC Biology

Fig. 3.

From: Lack of redundancy between electrophysiological measures of long-range neuronal communication

Fig. 3.

Directional metrics of inter-regional coupling in Gria1−/− and wild-type controls across 10 min novelty-induced activity. ac Parametric GC on log10 scale in the frequency bands indicated by greek letters and along the directional connections identified by the colour (blue: dHC➔PFC (a), vHC➔PFC (b), vHC➔dHC (c); orange: reverse of the before). Statistical indicators in the same colour identify a difference between genotypes (Sidak); statistical indictors in black (WT) or purple (KO) refer to a significant difference between the GC values of the two opposing directions within the colour-coded genotype whereby the location of the indicator identifies the direction with smaller average GC. df The same display as ac but for PDC. g Mean resultant vector length (MRL) as an indicator of SPC of prefrontal spikes to hippocampal theta. h Average theta phase angle of the mean resultant vector from SPC analysis. The theta phase corresponding to the degree value is shown on the right (horizontal axis illustrates voltage of LFP). i MRL as a function of lag between prefrontal MUA and hippocampal LFP. Some data was excluded based on lag amplitudes above 100 ms; contributing N numbers are stated; statistics identical to g. j Cross-correlation functions of instantaneous amplitude curves in the connections and frequency bands named at the top of each sub-panel with peak values indicated by a red dot. Statistical indictors in black (WT) or purple (KO) refer to a significant difference of the lag (temporal shift) from 0 ms (Wilcoxon’s signed rank test). k Spectra of coherence phase angle along the named connection. Dotted red lines and greek letters indicate analysed frequency bands. l Theta-gamma cross-regional PAC for the named directional connections. Solid lines display mean, and shaded area SEM throughout; bars display mean ± SEM throughout. Grey stars in gl indicate genotype differences (t test in g, i, j and l; Watson-Williams test in h and k). #p < 0.1; *p < 0.05; **p < 0.01; ***p ≤ 0.001

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