Fig. 1
From: Genetic dissection of the mitochondrial lipoylation pathway in yeast
Cartoon depicting the current model of the lipoylation process in eukaryotic mitochondria. Octanoylated ACP generated by mtFAS serves as a substrate for transfer of the C8 moiety by the octanoyl transferase Lip2 (LIPT2 in humans) to Gcv3, the H protein of the GCS (GCSH). The octanoyl moiety is then converted to the lipoyl cofactor by lipoyl synthase Lip5 (LIAS) and subsequently transferred to the E2 subunits of other ketoacid dehydrogenase complexes (depicted are Lat1 and Kgd2 of the S. cerevisiae PDH and KGD complexes) by lipoyl transferase Lip3 (LIPT1)