Fig. 5
From: Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans
Behavioral cross-tolerance is mediated by chemical structure-specific cytoprotective responses. a Benzaldehyde, its metabolite benzoic acid, and methyl-salicylate (MS) share similar chemical structures. b Representative epifluorescent microscopic images showing the effect of a 30-min exposure of 1 μl undiluted MS (ccMS) on DAF-16::GFP nuclear translocation and a 4-h of 1 μl ccMS exposure on cyp-35B1p::gfp and gst-4::gfp reporters expression. c Effect of preconditioning with ccMS (1 μl for 4 h, MS PC) or ccBA (BA PC) on 1 μl ccMS-induced lawn avoidance. d Effect of preconditioning with ccDA (DA PC) or ccBA on ccDA-induced lawn avoidance. Preconditioning and food leaving experiments were performed as indicated in Fig. 2. Error bars represent mean ± SEM compared to the respective naive values. N, number of independent experiments. p values were obtained by one-way ANOVA with Fisher’s LSD post hoc test. n.s., not significant; **p < 0.01, ***p < 0.001