From: Lack of drug-induced post-retrieval amnesia for auditory fear memories in rats
 | Experiment | Figure | Drug condition | n | Control condition | n | Evaluated drug effect | Statistical analysis | Result |
---|---|---|---|---|---|---|---|---|---|
Short-term effects on freezing behavior | Experiment 4 | 1i | Prop | 8 | Sal | 8 | Acute effect on freezing during tone CS (1 CS presentation) | Two-sided t test (reactivation CS) | t(14) = − 0.93, p = .37, d = 0.50 |
Luyten et al. in preparation | / | Prop | 29 | Sal | 26 | Acute effect on freezing during tone CS (12 CS presentations) | Two-sided t test (average of 12 CSs) | t(53) = − 2.36, p < .05, d = 0.65 | |
Experiment 7 | 3a | Ani | 10 | Veh | 12 | Short-term (4 h) effect on freezing before tone CS | Two-sided t test (STM test PreCS)* | t(20) = 8.14, p < .0001, d = 3.65 | |
Experiment 7 | 3a | Ani | 10 | Veh | 12 | Short-term (4 h) effect on freezing during tone CS (3 CS presentations) | Two-sided Welch’s t test (STM test average of CS1–3)* | t(12.76) = 4.20, p < .01, d = 1.74 | |
Experiment 7 | 3a | Cyclo | 14 | Veh | 12 | Short-term (4 h) effect on freezing before tone CS | Two-sided t test (STM test PreCS)* | t(24) = 4.36, p < .001, d = 1.79 | |
Experiment 7 | 3a | Cyclo | 14 | Veh | 12 | Short-term (4 h) effect on freezing during tone CS (3 CS presentations) | Two-sided t test (STM test average of CS1–3)* | t(24) = 3.46, p < .01, d = 1.42 | |
Long-term effects on body weight | Experiment 5 | 2e | Rap 20 | 8 | Veh | 8 | Effect on body weight (7d after injection) | Two-sided t test (increase from −5d to +7d) | t(14) = −10.35, p < .0001, d = 5.53 |
Experiment 6 | 2e | Rap 40 | 8 | Veh | 8 | Effect on body weight (7d after injection) | Two-sided t test (increase from −5d to +7d) | t(14) = −7.37, p < .0001, d = 3.94 | |
Experiment 7 | 3c | Ani | 10 | Veh | 12 | Effect on body weight (2d after injection) | Two-sided t test (increase from −2d to +2d) | t(20) = −2.55, p < .05, d = 1.14 | |
Experiment 7 | 3c | Cyclo | 14 | Veh | 12 | Effect on body weight (2d after injection) | Two-sided t test (increase from −2d to +2d) | t(24) = −5.44, p < .0001, d = 2.23 | |
Effects on memory consolidation | Experiment 8 | 3e | Cyclo | 12 | Veh | 12 | Effect on consolidation of tone fear memory (1d after injection) | Repeated-measures ANOVA (test 1, CS1-2-3)* | Group effect (F(1,22) = 5.53, p < .05, ηp2 = .20), Trial effect (F(2,44) = 8.79, p < .001, ηp2 = .29), no interaction |
Experiment 8 | 3g | Cyclo | 6 | Veh | 6 | Effect on consolidation of extinction memory (1d after injection) | Repeated-measures ANOVA (test 2, CS1-2-3)* | Trend for group by trial interaction (F(2,20) = 3.38, p = .05, ηp2 = .25), Trial effect (F(2,20) = 6.71, p < .01, ηp2 = .40), no Group effect | |
Experiment 8 | 3g | Cyclo | 6 | Veh | 6 | Effect on consolidation of extinction memory (1d after injection) | Repeated-measures ANOVA (test 1, last CS vs test 2, first CS) | Group by test interaction (F(1,10) = 5.64, p < .05, ηp2 = .36), Test effect (F(1,10) = 12.17, p < .01, ηp2 = .55), no Group effect |