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Table 2 The applied drugs do have other detectable physiological effects

From: Lack of drug-induced post-retrieval amnesia for auditory fear memories in rats

 

Experiment

Figure

Drug condition

n

Control condition

n

Evaluated drug effect

Statistical analysis

Result

Short-term effects on freezing behavior

Experiment 4

1i

Prop

8

Sal

8

Acute effect on freezing during tone CS (1 CS presentation)

Two-sided t test (reactivation CS)

t(14) = − 0.93, p = .37, d = 0.50

Luyten et al. in preparation

/

Prop

29

Sal

26

Acute effect on freezing during tone CS (12 CS presentations)

Two-sided t test (average of 12 CSs)

t(53) = − 2.36, p < .05, d = 0.65

Experiment 7

3a

Ani

10

Veh

12

Short-term (4 h) effect on freezing before tone CS

Two-sided t test (STM test PreCS)*

t(20) = 8.14, p < .0001, d = 3.65

Experiment 7

3a

Ani

10

Veh

12

Short-term (4 h) effect on freezing during tone CS (3 CS presentations)

Two-sided Welch’s t test (STM test average of CS1–3)*

t(12.76) = 4.20, p < .01, d = 1.74

Experiment 7

3a

Cyclo

14

Veh

12

Short-term (4 h) effect on freezing before tone CS

Two-sided t test (STM test PreCS)*

t(24) = 4.36, p < .001, d = 1.79

Experiment 7

3a

Cyclo

14

Veh

12

Short-term (4 h) effect on freezing during tone CS (3 CS presentations)

Two-sided t test (STM test average of CS1–3)*

t(24) = 3.46, p < .01, d = 1.42

Long-term effects on body weight

Experiment 5

2e

Rap 20

8

Veh

8

Effect on body weight (7d after injection)

Two-sided t test (increase from −5d to +7d)

t(14) = −10.35, p < .0001, d = 5.53

Experiment 6

2e

Rap 40

8

Veh

8

Effect on body weight (7d after injection)

Two-sided t test (increase from −5d to +7d)

t(14) = −7.37, p < .0001, d = 3.94

Experiment 7

3c

Ani

10

Veh

12

Effect on body weight (2d after injection)

Two-sided t test (increase from −2d to +2d)

t(20) = −2.55, p < .05, d = 1.14

Experiment 7

3c

Cyclo

14

Veh

12

Effect on body weight (2d after injection)

Two-sided t test (increase from −2d to +2d)

t(24) = −5.44, p < .0001, d = 2.23

Effects on memory consolidation

Experiment 8

3e

Cyclo

12

Veh

12

Effect on consolidation of tone fear memory (1d after injection)

Repeated-measures ANOVA (test 1, CS1-2-3)*

Group effect (F(1,22) = 5.53, p < .05, ηp2 = .20), Trial effect (F(2,44) = 8.79, p < .001, ηp2 = .29), no interaction

Experiment 8

3g

Cyclo

6

Veh

6

Effect on consolidation of extinction memory (1d after injection)

Repeated-measures ANOVA (test 2, CS1-2-3)*

Trend for group by trial interaction (F(2,20) = 3.38, p = .05, ηp2 = .25), Trial effect (F(2,20) = 6.71, p < .01, ηp2 = .40), no Group effect

Experiment 8

3g

Cyclo

6

Veh

6

Effect on consolidation of extinction memory (1d after injection)

Repeated-measures ANOVA (test 1, last CS vs test 2, first CS)

Group by test interaction (F(1,10) = 5.64, p < .05, ηp2 = .36), Test effect (F(1,10) = 12.17, p < .01, ηp2 = .55), no Group effect

  1. Statistical evaluation of other effects of propranolol, rapamycin, anisomycin, or cycloheximide suggests that the drugs (same dose and route as in Table 1) do have detectable physiological effects. Ani anisomycin (150 mg/kg), Cyclo cycloheximide (1.5 mg/kg), Prop propranolol (10 mg/kg), Rap 20 rapamycin (20 mg/kg), Rap 40 rapamycin (40 mg/kg), Sal saline, Veh vehicle; *preregistered analysis