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Fig. 7 | BMC Biology

Fig. 7

From: A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

Fig. 7

ELISA-based serological analyses of rBCLA presence in the sera of mice. a ELISA serological titration of rBCLA reactivity in mice over time and for a given T. gondii strain. Individual ELISA measurements given in UI are grouped according to T. gondii strain type with cystogenic strains (ME49, PruA7, 76K; red spots), the non-cystogenic strain RH (green stars), the culture-attenuated strains (Pruku80, CTG; green stars), and Δbcla strains (in 76K or Pruku80 backgrounds; blue triangles). A time segmentation post-infection is displayed to distinguish between the acute phase (≤ 8 days) and chronic phase (≥ 21 days). b rBCLA ELISA reactivity correlation with parasitic load, miR-155, and miR-146a expression. Superposed titrations of rBCLA IgGs (in UI), parasitic load (in parasite qPCR count), and miR-155/miR-146a are shown for different mouse strains (NMRI, BALB/c), non-infected or infected with different T. gondii strains all within a chronic infection timeframe (≥ 11 weeks). Cystogenic strains (ME49, PruA7, 76K; red circles), the non-cystogenic strain RH (green stars), the culture-attenuated strains (Pruku80, CTG; green stars), and Δbcla strains (in 76K or Pruku80 backgrounds; blue triangles) were used

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