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Fig. 7 | BMC Biology

Fig. 7

From: The CRK2-CYC13 complex functions as an S-phase cyclin-dependent kinase to promote DNA replication in Trypanosoma brucei

Fig. 7

Model of CRK2-mediated phosphorylation of Mcm3 and its effect on DNA replication. Prior to the initiation of DNA replication, the Mcm2–7 complex was first loaded onto chromosomes, followed by the loading of Cdc45, likely through interactions with Mcm2 and Mcm5. Subsequently, CRK2 phosphorylates Mcm3 at Thr-310 and Ser-213, and phosphorylation of Thr-310 promotes the recruitment of the GINS complex to the Mcm2–7 complex, leading to the formation of the CMG complex and then the initiation of DNA replication. When CRK2 is deficient, the GINS complex is not recruited, and the CMG complex is not formed, thereby preventing the initiation of DNA replication

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BMC Biology

ISSN: 1741-7007

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