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Table 2 Disease-associated factors that impact plasma membrane resistance and repair

From: Plasma membrane integrity: implications for health and disease

Impact Protein Disease Refs
Lung
    Resistance, repair CAV1, MG53 Idiopathic pulmonary fibrosis [240, 241]
Gastrointestinal tract
    Resistance, repair CAPN8, CAPN9 Gastropathies [242]
    Repair ANXA4 Gastric cancer [243]
ATG16L1 Inflammatory bowel disease [13]
GPX4 Inflammatory bowel disease [19]
Skin
    Resistance FLG Atopic dermatitis [221]
Vasculature
    Repair VWF Von Willebrand disease [225]
ANXA2 Behcet’s disease [244]
Liver
    Resistance MDR3 Familial intrahepatic cholestasis [228]
Kidney
    Repair MG53 Acute kidney injury [245]
Muscle
    Resistance DMD Duchenne’s muscular dystrophy [246]
DAG1 Dystroglycanopathy [247]
    Repair DYSF Limb-girdle muscular dystrophy type 2B [125]
CAV3 Limb-girdle muscular dystrophy type 1C [196]
ANO5 Limb-girdle muscular dystrophy type 2 L [173]
PTRF Lipodystrophy [248]
MICU1 Neuromuscular disorder [174]
ANXA6 Limb-girdle muscular dystrophy type 2C [249]
ASM Niemann-Pick type A/B [235]
CAPN-1, −2, −3 Calpainopathies [34, 113, 250]
MCOLN1 Mucolipidosis type IV [112]
SYT7 Autoimmune myositis [251]
HRK Myositis [252]
Heart
    Repair DYSF Limb-girdle muscular dystrophy type 2B [238]
MG53 Valvular heart disease [253]