Fig. 2

Effect of regulatory elements on gene transcription regulation. a Boxplots of transcription for genes associated with active promoter, poised promoter, and bivalent promoter. ** represents p value < 0.01. b Segmentation state, H3K27ac, H3K4me3, H3K27me3, and RNA-seq profiles on chromosome 16: 77.7–78.2 Mb. Promoters of NUDT7, VAT1L, CLEC3A, and WWOX are highlighted (blue shading) and enlarged. c Boxplots of transcription for genes associated with active enhancer and repressed state. ** represents p value < 0.01. d Distribution of distance between regulatory elements and TSS of their nearest genes. e Boxplots of transcription for genes by active enhancer with corresponding distance. ** represents p value < 0.01