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Fig. 6 | BMC Biology

Fig. 6

From: Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

Fig. 6

Luteolin is neuroprotective in models of HD. a, b YAC128 cortical neurons were treated with luteolin at indicated concentrations for 16 h. OCR was quantified using a Seahorse analyzer and basal respiration, maximal respiration, ATP production (oligomycin-sensitive respiration), and spare respiratory capacity (SRC) were calculated after the sequential injection of oligomycin (1 μM), FCCP (1 μM), and Ant A plus rotenone (0.5 μM) (n = 5 run in duplicate or triplicates; each point in the graph represents one independent culture). c Adult C. elegans carrying rmIs110 transgene were exposed to DMSO (as a control) or luteolin (25 μM) for 96 h and trashing assay was performed (n = 41 from 3 biological replicates). Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by non-parametric Kruskal-Wallis test (in b); unpaired t test **p = 0.0037 (in c)

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