Skip to main content
Fig. 5 | BMC Biology

Fig. 5

From: A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants

Fig. 5

Basal B-like patients express hallmarks of EMT and metastasis that leads to a poor prognosis. a Lehman classification for basal A- and B-like patients. **p < 0.01 in Fisher’s exact test, two tail, comparing basal B to basal A. b Gene Set Enrichment Analysis (GSEA) of the genes differentially expressed between basal A- and B-like patients. Hallmark EMT and inflammatory response signatures are enriched in basal B-like patients. c. Box plots of the median and 25th percentile of the expression levels (in TPM) of major epithelial and mesenchymal-like EMT markers in basal A-like (blue) and basal B-like (red) patients. d Box plot of the mean and 25th percentile of the expression levels (in TPM) of Basal-like non-invasive and mesenchymal-like invasive markers in basal A-like (blue) and basal B-like (red) patients. ** P < 0.01, *** P < 0.001, **** P < 0.0001 in Wilcoxon rank-sum test comparing basal A-like to basal B-like

Back to article page