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Fig. 6 | BMC Biology

Fig. 6

From: A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants

Fig. 6

The basal B-specific splicing signature is co-regulated by ESRP1 and RBM47. a Heatmap of transcripts per million values for RNA binding proteins (RBP) differentially expressed in basal A and basal B cell lines (P value < 10− 9 by Kruskal-Wallis test). b Box plots of the mean and 25th percentile of the expression levels (in TPM) of the same RBP as in a, but in basal A-like and basal B-like patients. c, d Venn diagrams of the number of splicing events from the basal B-specific splicing signature dependent on the splicing factors (SF) ESRP1/2 and RBM47 using a cutoff of |DeltaPsi| > 0.1 and a higher probability > = 0.95. eg Heatmaps of the PSI values of the ESRP and RBM47-dependent exons from c and d in ESRP1/2 knock downed H358 cells, RBM47 overexpressed MDA-MB-231 cells and RBM47 knock downed H358 cells. h, i Kaplan-Meier plots for overall survival in basal-like TCGA patients expressing the highest tercile (blue) or the lowest tercile (red) of ESRP1 and RBM47 expression levels. HR (hazard ratio) and logrank p values (P) discriminating between groups are shown

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