Multi-omic profiling of pituitary thyrotropic cells and progenitors

Table 2 Gene ontology term enrichment

GHFT1 cells								TαT1 cells
Gene	Structure and development¹					Expression		Gene	Synapse development and function²					Expression
Gene	A	B	C	D	E	GHFT1	TαT1	Gene	F	G	H	I	J	GHFT1	TαT1
Cyr61	X	X	X	X	X	117.1	0.5	Nrxn1	X	X	X	X	X	0.0	4.2
Edn1	X	X	X	X	X	7.3	0.0	Unc13a	X	X	X	X	X	0.0	19.8
Bmp4	X	X	X	X	X	6.8	0.0	Drd2	X	X		X	X	0.0	12.4
Tgfbr2	X	X	X	X	X	65.1	0.0	Chrnb2	X	X		X	X	0.0	12.7
Fgf10	X	X	X	X	X	1.1	0.0	Grin1	X	X		X	X	0.0	20.5
Gli3	X	X	X	X	X	13.4	0.0	Syt4	X	X		X	X	0.0	86.3
Mef2c	X	X	X	X	X	7.6	0.0	Grin3a	X	X		X	X	0.0	11.4
Cav1	X	X	X	X	X	10.1	0.0	Snap25	X	X		X	X	0.1	107.4
Bmp5	X	X	X	X	X	3.8	0.0	Sez6	X	X	X	X	X	0.0	39.8
Ctgf	X	X	X	X	X	40.3	0.0	Gabrg2	X	X	X	X	X	0.0	13.0
Gli2	X	X	X	X	X	4.2	0.0	Pclo	X	X	X	X	X	0.0	4.0
Gata6	X	X	X	X	X	1.2	0.0	Atp2b2			X	X		0.0	9.4
Tbx20	X	X	X	X	X	2.2	0.0	Chrna4	X	X			X	0.0	3.4
Msx2	X	X	X	X	X	20.1	0.0	Shisa6	X	X			X	0.0	11.3
Yap1	X	X	X	X	X	40.3	0.2	Lrrc4c			X	X		0.0	1.7
Sfrp1	X	X	X	X	X	7.1	0.0	Thy1				X		0.0	23.3
Hlx	X	X	X	X	X	1.5	0.0	Glra3	X	X	X		X	0.0	28.1
Cxcl12	X	X	X	X	X	4.2	0.0	Adgfb1			X	X		0.0	9.5
Pax3	X	X	X	X	X	9.1	0.0	Gria1	X	X			X	0.0	11.7
Fn1	X	X	X	X	X	611.8	1.0	Lgi1				X		0.0	1.1

¹ The top five GO terms associated with the top 5% of the most differentially expressed genes (log 2-fold-change) in GHFT1 cells are A = animal organ development, B = anatomical structure development, C = anatomical structure morphogenesis, D = multicellular organism development, E = system development. X’s illustrate the association of each gene with a GO term. Expression is given in FPKM
² The top five GO terms associated with TαT1 cells are: F = synaptic signaling, G = trans-synaptic signaling, H = synapse organization, I = nervous system development, J = anterograde trans-synaptic signaling

ISSN: 1741-7007