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Fig. 5. | BMC Biology

Fig. 5.

From: A comprehensive survey of developmental programs reveals a dearth of tree-like lineage graphs and ubiquitous regeneration

Fig. 5.

Regeneration trajectories. a, b Schematics of regeneration trajectories.Yellow circles represent cell types in a homeostatic organism, and black edges represent lineage relationships. Adult pluripotent cells are outlined in red. Red edges represent lineage relationships between the organism’s cell types during regeneration. a Here, the root node is the only adult pluripotent cell and regeneration trajectories exactly match the paths in the lineage graph. In cases where signaling does not play a role in determining cell fate, all regeneration trajectories are of this kind. b Here, a non-root node is a pluripotent cell, and therefore, necessarily, regeneration trajectories cannot be perfectly aligned with paths in the lineage graph. In these cases, signaling is definitely involved in governing cell fates. Dashed red edges imply that cell-types other than those present in the homeostatic organism may be produced during regeneration. c Stacked histograms for cell types of different categories pooled from organisms with different lineage graph topologies. Different cell type categories are represented with different colors. Non-pluripotent cells are represented in grays; root nodes: light gray; not non-root nodes: dark gray. Adult pluripotent cells are represented in colors: root nodes: light brown, non-root nodes: dark brown. Heights of colored blocks represent the proportions of corresponding cell types. A total of 1,217,108 graphs were used to generate this plot. d Scatter plot showing the maximum path lengths across lineage graphs vs the lengths of regeneration trajectories from pluripotent root nodes for acyclic lineage graphs that contain them. Each point represents an organism. Noise and transparency has been added to the position of points to make their density more apparent. A total of 699,986 graphs were used to generate this plot

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