Fig. 8

D2-Mx1^r/r infections with DI244 material. Female 8–12 weeks old D2-Mx1^r/r mice were intra-nasally infected with 20 μL solution containing 10 μL of DI244 material produced in shake flask (active, 1.5E+6 PFU per mouse; or UV-inactivated) and 1000 FFU PR8 in PBS at day 0. STV (n = 10): D2-Mx1^r/r mice infected with PR8 STV; STV + active DI244 (n = 12): D2-Mx1^r/r mice infected with PR8 STV and treated with active DI244; STV + inactive DI244 (n = 10): D2-Mx1^r/r mice infected with PR8 STV and treated with UV-inactivated DI244. a Body weight loss curves of treated mice in percent body weight relative to day 0. Error bars indicate the SEM for body weight changes. Statistically significant differences for body weight loss between active DI244 treated group and all other groups were assessed by unpaired two-tailed t test (**: p < 0.001). b Kaplan-Meyer survival curves. The survival rate for mice treated with active DI244 was significantly higher than for all other groups (log rank test; p < 0.0001). The survival rate for mice treated with inactive DI244 was not significant different from STV only infected mice (p = 0.63)