Fig. 5

G9a buffers the activation of stress-specific resistance genes. We selected genes that were uniquely overinduced in only one of the five G9a-depleted datasets and were annotated with the specific GO terms “response to oxidative stress,” “immune response,” and “response to hypoxia.” Based on published evidence, we classified the function of each gene in the stress response in the following categories: detection (proteins that are involved in sensing the stress), resistance (proteins are directly involved in eliminating the stress), gene regulation (transcription factors, translation regulators, chromatin regulators, and cofactors that activate or repress a stress-responsive transcription factor), signaling (any molecule involved in a signal transduction pathway), and unknown (annotated in stress response based on a mutant phenotypes or transcriptional response without mechanistic understanding)