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Table 1 Identification of G9a-dependent stress-responsive genes

From: The epigenetic regulator G9a attenuates stress-induced resistance and metabolic transcriptional programs across different stressors and species

Dataset short name

Organism

Tissue or cell line

Type of stress

Exposure Time (h)

Stress-responsive genes1

G9a-dependent stress-responsive genes2

Percentage of stress-responsive genes dependent on G9a

Oxidative stress Drosophila

Dm

Whole head

Oxidative stress

6, 12

5737

2243

39%

Virus Drosophila

Dm

Fat body

Viral infection

24

2560

1290

50%

Interferon MEF

Mm

Embryonic fibroblasts

Interferon

6, 12

7311

2130

29%

Hypoxia ES

Mm

Embryonic stem cells

Hypoxia

4, 24

4165

1365

32%

Hypoxia MCF-7

Hs

MCF-7 cells

Hypoxia

4, 24

3757

1994

53%

  1. Dm - Drosophila melanogaster, Mm - Mus musculus, Hs - Homo sapiens
  2. 1Stress-responsive genes are defined as a having significantly different expression levels (p-adj < 0.05, fold change > 1.2) in response to stress in controls or in G9a depleted conditions
  3. 2Stress-responsive genes that also have significantly different expression in G9a-depleted conditions compared to controls (p-adj < 0.05, fold change > 1.2)