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Fig. 1 | BMC Biology

Fig. 1

From: The CAT-SIR is out of the bag: tumors prefer host rather than dietary nutrients

Fig. 1

CATSIR is a method to determine whether tumors acquire nutrients from the host versus from the diet. Holland et al. took advantage of the fact that biomass from C3 and C4 plants have different ratios of 13C and 12C carbon. In their study, RasV12, scrib−/− D. melanogaster larvae were reared on a nutrient source derived from C3 plants for 6 days, which results in the larvae biomass having a 13C/12C ratio that approximates that of C3 plants. The larvae were then shifted to a nutrient source derived from C4 plants with a different 13C/12C ratio prior to isolating tumors. Thus, the ratio of 13C/12C ratio in the tumors reports the extent to which tumor nutrients were derived from host tissues versus from the diet

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