Fig. 2

SMS-based expression and co-expression analyses for various drug treatments. a Distributions of the numbers of DE mRNAs (left) and vlincRNAs (right). The yellow inner circles represent mRNAs or vlincRNAs expressed in K562; the orange and green middle sections represent respectively up- or downregulated transcripts in at least one drug treatment; the orange and green outer sections represent respectively up- or downregulated transcripts in all drug treatments. b, c Numbers of DE vlincRNAs (b) and mRNAs (c) for each indicated treatment. The blue and orange bars represent respectively up- and downregulated transcripts. d Fractions of DE vlincRNAs validated by qPCR in each indicated treatment. e Box plots representing numbers genes found in either negative and positive co-expression-based vlincRNA networks