Fig. 6

Effect of vlincRNA knockdowns using CRISPR/Cas13 on relative fold changes of the co-expressed genes. a Schematic representation of the expected connection between the either positively or negatively co-expressed genes (left) and the corresponding change in expression level in response to a vlincRNA knockdown (right). b–e Relative differences in the fold changes between negatively and positively co-expressed genes for each gRNA targeting-control pair (bottom). The relative differences were calculated as Cohen’s d metrics (b, d) or differences of medians (c, e) by either combining the data for both time points (3 and 6 days) (b, c) or analyzing them separately (d, e). More details in the text