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Fig. 4 | BMC Biology

Fig. 4

From: The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon

Fig. 4

Late regionalisation of the telencephalic-like domain in amphioxus. ad The expression of Pax4/6, eh Nkx2.1 and il Hh, all shown in serial coronal paraffin sections from ventral to dorsal, with the ventricle of the cerebral vesicle (cv) centred in the images. In all cases, the anterior part of the brain is at the top of the image. ad Pax4/6 is expressed ventrally in the posterior half of the cerebral vesicle but in a salt-and-pepper pattern (a, b) and progressively anteriorises as the expression becomes dorsal (c, d). eh Nkx2.1 is also expressed ventrally in the posterior half of the cerebral vesicle (ef), but as in the case of Pax4/6, it becomes anterior in the upper layers of the brain, where it marks the anterior neural border (g, h). il Hh, on the other hand, is broadly expressed throughout the cv, with expression gradually fading away in a dorsal direction (this is best appreciated in Additional file 7 Figure S7). mp summarises the expression of all the genes at the respective sections. All scale bars in amphioxus sections are 50μm. Arrowheads indicate the pigment of the frontal eye. Asterisks indicate the position of the infundibular organ. Abbreviation: NP neuropore. Full series of sections are shown in Additional files 5, 6 and 7 Figures S5-S7

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