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Fig. 10 | BMC Biology

Fig. 10

From: The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus

Fig. 10

Silencing GlyT2+ PnC neurons during acoustic prepulses decreases PPI. a Schematic of the hypothesis being tested in GlyT2-Cre mice injected with a Cre-dependent AAV encoding Archaerhodopsin-eYFP (Arch3.0-eYFP). b Graph showing no significant effect of green light paired with 70–120 dB acoustic startling pulses on basal startle amplitude [light: (F(1,7) = 1.407, p = 0.274); intensity × light interaction:(F(3,21) = 1.747, p = 0.188)]. c Graph showing no significant main effect of light during 120 dB pulses presented before (basal) vs. randomly during the PPI task, on mean baseline startle amplitude (F(1) = 3.124, p = 0.105). d Graph showing that green light paired with acoustic prepulses significantly decreased PPI in mice injected with Arch3.0, at ISIs between 30 and 100 ms. We found a significant effect of ISI (F(6,42) = 8.957, p < 0.001) and light (F(1,7) = 8.216, p = 0.024) (two-way RM ANOVA). N = 8 mice per group. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01

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