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Fig. 8 | BMC Biology

Fig. 8

From: The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus

Fig. 8

CeA glutamatergic inputs activate GlyT2+ PnC neurons via AMPA and NMDA receptors. a Top, Injection of AAVDJ-CamKIIα-ChR2-eYFP in the CeA and injection of Cre-dependent AAVDJ-tdTomato in the PnC of GlyT2-Cre mice, followed by in vitro patch clamp recordings. Bottom, Schematic of the hypothesis being tested. b Paired-pulse ratios of the light-evoked EPSPs (top) and EPSCs (bottom) at 50- and 100-ms interstimulus intervals (ISIs). Insets: Representative traces. c Graph showing the amplitude of the light-evoked EPSPs recorded in GlyT2+ PnC neurons in control, during the sequential bath application of AP5 and DNQX and following washout. Insets: Sample traces. Scale: 10 mV/15 ms. Representative of N = 10 mice, n = 38 neurons. Data are represented as mean ± SEM. *P > 0.05, **P > 0.01. Scale bars: b Voltage traces: 2 mV/10 ms; Current traces: 5 pA/5 ms

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