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Fig. 6 | BMC Biology

Fig. 6

From: Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila

Fig. 6

In vivo labelling studies demonstrate that strictosidine is a key intermediate involved in CPT biosynthesis in O. pumila. ac Metabolites (d5-tryptophan [i], d4-strictosidine [ii], d4-strictosidinic acid [iii]) detected by LC-MS in extracts from feeding experiments with three different deuterium-labelled substrates: d4-pumiloside (a), d4-deoxypumiloside (b), and d4-camptothecin (c). Extracted ion chromatograms (EICs) of deuterium-labelled intermediates were compared

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