Fig. 6
From: Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
In vivo labelling studies demonstrate that strictosidine is a key intermediate involved in CPT biosynthesis in O. pumila. a–c Metabolites (d5-tryptophan [i], d4-strictosidine [ii], d4-strictosidinic acid [iii]) detected by LC-MS in extracts from feeding experiments with three different deuterium-labelled substrates: d4-pumiloside (a), d4-deoxypumiloside (b), and d4-camptothecin (c). Extracted ion chromatograms (EICs) of deuterium-labelled intermediates were compared