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Fig. 3 | BMC Biology

Fig. 3

From: Large-scale genomic analysis reveals the genetic cost of chicken domestication

Fig. 3

Testing the function of TSHR-Gly559Arg using transgenic mouse model assay. a Photograph showing TSHR-559Arg knock-in homozygous (HO) and wild-type (WT) mice at 4 months old. b Bar plot shows that HO mice have significantly lower body weight than wild-type mice. c No difference in total locomotive ability between HO and wild-type mice. df HO mice have significantly lower oxygen consumption (VO2), calorie consumption, and carbon dioxide exhalation (VCO2) compared to wild-type mice. In b, n = 6 HO and n = 8 WT female and n = 8 HO and n = 8 WT male 4-week-old mice, as well as n = 7 HO and n = 7 WT female and n = 12 HO and n = 14 WT male 10-week-old mice were analyzed. In cf, n = 8 for both HO and WT male mice were analyzed for each test. *P < 0.05; **P < 0.01;***P < 0.001; ****P < 0.0001. Statistical significance was measured by Student’s t-test (two-tailed)

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