Fig. 4

NPM levels increase in plasma of mice treated with Dox. a In vivo experimental design. Ten female C57Bl/6 wild-type mice aged 8 to 10 weeks were randomly divided into two groups. In the first group (Dox, n = 5), Dox was administered in six equal intraperitoneal injections over a period of 2 weeks. In the second group (saline, n = 5), control mice were treated with physiological saline in the same manner as the regimens for the Dox group. Both groups then followed a 4-week recovery period. b NPM levels in mice plasma were analysed by ELISA assay at day 42, following 2-week treatment with Dox (black bar) or saline (white bar) and 4 weeks recovery (^*P <0.05). Five female C57Bl/6 wild-type mice aged 8 to 10 weeks were used for each group