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Fig. 4 | BMC Biology

Fig. 4

From: The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

Fig. 4

The effects of hypoxia acclimation on red blood cell O2 affinity and arterial O2 saturation differed between hemoglobin (Hb) genotypes in F2 inter-population hybrid deer mice, but the effects of hypoxia acclimation on O2max did not. a Red blood cell P50 (O2 pressure at which Hb is 50% saturated) and b arterial O2 saturation at O2max in hypoxia, measured before and after a 6-week acclimation to hypobaric hypoxia (12 kPa O2). P < 0.05 vs. pre-acclimation value within a genotype. P < 0.05 between genotypes within an acclimation condition for values not sharing a letter. c The change in hypoxic O2max plotted against the change in arterial O2 saturation in hypoxia in individuals in response to hypoxia acclimation (mean ± SEM for each genotype are shown as error bars). See Fig. 2 for other details on Hb genotypes

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