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Fig. 5 | BMC Biology

Fig. 5

From: The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

Fig. 5

Effects of increasing tissue O2 diffusing capacity (DTO2) on hypoxic O2max and O2 partial pressures (PO2) using mathematical modeling of the O2 transport pathway. a Relative changes in hypoxic O2max and b changes in alveolar (PAO2), arterial (PaO2), and venous (PvO2) PO2 in response to relative increases in DTO2. The effects were modeled using the mean (bold lines) ± SEM (fine lines) values of red blood cell P50 for mice with hemoglobin genotypes that were most characteristic of lowlanders (αLLβLH) and highlanders (αHHβHH)

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