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Fig. 2. | BMC Biology

Fig. 2.

From: Disruption of left-right axis specification in Ciona induces molecular, cellular, and functional defects in asymmetric brain structures

Fig. 2.

Disruptions to the ocellus caused by early and late dechorionation. a, b Pigment cells in representative non-dechorionated and late-dechorionated larvae, respectively. cf Representative larvae showing a range of pigment cell defects in early-dechorionated larvae, including overlapping otolith and ocellus at the midline (ocellus is outlined in blue) (c); two pigmented structures both resembling otoliths (d, see also i); a single large pigment spot—possibly two cells (e); and two pigmented structures, both resembling ocelli (f). gl Photoreceptors in early- and late-dechorionated larvae immunostained with anti-Arrestin. g Late-dechorionated larva. h Early-dechorionated larva showing left-right reversal of photoreceptors. i, j Examples of early-dechorionated larvae with abnormal numbers and locations of photoreceptors. k, l Late- and early-dechorionated larvae, respectively, showing apparently normal photoreceptor development in the late-dechorionated larva, while in the early-dechorionated larva the photoreceptor cluster is reversed, and while most projections are targeted correctly, one or more is projecting posteriorly. White arrows indicate properly targeted photoreceptor projections, and red arrows indicate aberrant photoreceptor projections. Asterisk indicates the location of the Group II photoreceptors. Abbreviations: ot, otolight; oc, ocellus; pp, palp; dechor, dechorionation; L, left; R, right

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