From: Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis
AMR gene | Name in figures | Resistance conferred (Antibiotic Class) | No. of isolates | Reported in S. suis | Reported in other species (CARD and NCBI) | Reported genetic location in S. suis or other species |
---|---|---|---|---|---|---|
ant(4’)-Ib | ant4Ib | Aminoglycoside | 1 | This report | Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus spp. | Plasmid |
ant(6’)-Ia/aadE | ant6Ia | Aminoglycoside | 56 | [21] | Staphylococcus epidermidis, Streptococcus spp., Enterococcus faecalis | Plasmid, ICE |
ant(6’)-Ib | ant6Ib | Aminoglycoside | 12 | This report | Campylobacter spp., Bacillus subtilis, Clostridium spp. | Pathogenicity Island |
ant(9’)-Ia/spw/aad9 | ant9Ia | Aminoglycoside | 45 | [21] | Staphylococcus aureus, Enterocoocus spp., Staphylococcus spp. | Plasmid, ICE |
aph(3’)-IIIa | aph3IIIa | Aminoglycoside | 46 | [32] | Campylobacter spp., Staphylococcus spp., Streptococcus spp., Enterococcus spp. | Plasmid, transposon |
ant1* | ant1 | Aminoglycoside | 12 | This report | Campylobacter spp., Clostridium difficile, Lactobacillus amylovorus | Plasmid, ICE |
aadE1* | aadE1 | Aminoglycoside | 2 | This report | Enterococcus faecium, Staphylococcus aureus | Plasmid |
aadE2* | aadE2 | Aminoglycoside | 5 | This report | Clostridium spp., Campylobacter fetus | ICE |
ermB | ermB | MLSB (Macrolide/ Lincosamide | 370 | [33] | Campylobacter spp., Clostridium spp., Enterococcus spp., Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Shigella spp., Staphylococcus spp., Streptococcus spp., Vibrio vulnificus. | Plasmid, ICE |
ermG | ermG | MLSB (Macrolide/ Lincosamide | 1 | This report | Clostridium difficile, Enterococcus faecium | Conjugative transposon |
ermT | ermT | MLSB (Macrolide/ Lincosamide) | 3 | This report | Enterococcus faecium, Staphylococcus aureus, Streptococcus spp. | Plasmid |
mefA | mefA | Macrolide | 11 | [33] | Streptococcus spp., Enterococcus faecium, Haemophilus parainfluenzae, Proteus mirabilis | Transposon, ICE |
mel/msrD | mel | Macrolide | 9 | [33] | Streptococcus spp., Enterococcus faecium, Haemophilus parainfluenzae, Proteus mirabilis. | Transposon, ICE |
lnuB | lnuB | Lincosamide | 3 | [19] | Enterococcus spp., Staphylococcus spp., Streptococcus agalactiae | Plasmid |
linB | linB | Lincosamide | 42 | [34] | Â | Â |
lnuC | lnuC | Lincosamide | 9 | [35] | Campylobacter spp., Clostridium difficile, Streptococcus agalactiae. | Plasmid |
lsaE | lsaE | Pleuromutilin | 43 | [19] | Enterococcus spp., Staphylococcus spp., Streptococcus agalactiae. | Plasmid, ICE |
tet44 | tet44 | Tetracycline | 4 | This report | Clostridium spp. | ICE |
tetM | tetM | Tetracycline | 81 | [21] | Streptococcus spp., Escherichia coli, Staphylococcus spp., Enterococcus spp., Klebsiella pneumonia, Neisseria meningitides, Clostridium difficile, Salmonella enterica | Plasmid, ICE |
tetM1* | tetM1 | Tetracycline | 34 | This report | Staphylococcus spp., Streptococcus spp., Enterococcus spp., Bacillus spp., Clostridium spp. | Plasmid, transposon |
tetM2* | tetM2 | Tetracycline | 43 | This report | Enterococcus spp., Clostridium difficile. | Â |
tetM3* | tetM3 | Tetracycline | 13 | This report | Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus spp., Clostridium spp. | Transposon, ICE |
tetO | tetO | Tetracycline | 465 | [21] | Campylobacter spp. | ICE, plasmid |
tetO1* | tetO1 | Tetracycline | 2 | This report | Dorea spp., uncultured bacterium | Conjugative transposon |
tetW | tetW | Tetracycline | 8 | [18] | Streptococcus agalactiae, Clostridium difficile, Chlamydia trachomatis. | Plasmid |
tet40 | tet40 | Tetracycline | 7 | Clostridium difficile | Composite mobile genetic element, ICE | |
tetL | tetL | Tetracycline | 12 | [21] | Streptococcus spp., Escherichia coli, Staphylococcus spp., Enterococcus spp., Klebsiella pneumoniae. | Plasmid |
tet(O/W/32/O) †| tetO:W:32:O | Tetracycline | 20 | [37] |  | ICE |
dfrF | dfrF | TMP | 11 | This report | Clostridium difficile, Enterococcus spp., Staphylococcus aureus, Streptococcus agalactiae | plasmid |
dfrK | dfrK | TMP | 7 | This report | Staphylococcus aureus, Staphylococcus epidermidis. | plasmid |
vgaF* | vgaF | Pleuromutilin | 173 | This report | Not known | Chromosome. Found as an intact gene (~ 1386 bp) or truncated (< 750 bp) |
cat* | cat | Florfenicol | 3 | This report | Enterococcus faecalis, Streptococcus iniae, Listeria monocytogenes, Staphylococcus aureus | Plasmid, Transposon |
dhfr* | DHFR102 | TMP | 235 | This report | Mutations in I100L in Streptococcus spp. and Staphylococcus aureus | DHFR: I102L |
dhfr promoter* | DHFRPromoter | TMP | 86 | This report | None reported | DHFR : A5G upstream/indels 0-30 bp upstream |
pbp2B/penA* | PBP2B:hap | Penicillin | 181 | This report | Mutations in other locations in Streptococcus pneumonia and Group B Streptococcus spp | PBP2B : K479T/A, D512E/Q/K/A, K513E/D,T515S |
pbp2X* | PBP2X:hap | Ceftiofur | 93 | This report | None reported | PBP2X : M437L, S445T, T467S Y525F |
pbp2X | PBP2X551 | Penicillin | 153 | This report | Mutation in PBP2X in S. pneumoniae (T550), group B streptococci (T555) and S. pyogenes (T553) | PBP2X : T551S |
pbp2X | PBP2X594:596 | Penicillin | 15 | [38] | Streptococcus suis. Mutations in other locations in Streptococcus pneumonia, Group B Streptococcus sp. and Streptococcus uberis | PBP2X : L594Y/F, V596G |
pbp2X | PBP2X569 | Penicillin | 10 | [38] | Â | PBP2X : N569Q |
mraY* | MraY:hap | Penicillin | 62 | This report | None reported | MraY : M6I/L and either A4S/T or G8S |
parC†| ParC79 | Fluoroquinolone | 4 | [39] | Escherichia coli, Pseudomonas aeruginosa, Streptococcus spp., Staphylococcus aureus | ParC : S79 |
gyrA†| GyrA81 | Fluoroquinolone | 13 | [39] | Escherichia coli, Klebsiella spp., Streptococcus spp., Staphylococcus aureus | GyrA : S81 |
gyrA†| GyrA85 | Fluoroquinolone | 1 | [39] | Escherichia coli, Klebsiella spp., Streptococcus spp., Staphylococcus aureus | GyrA : E85 |