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Table 1 Expression of the selected genes in the spiralian brains

From: Molecular and morphological analysis of the developing nemertean brain indicates convergent evolution of complex brains in Spiralia

Species Clade Brain type Gene expression in the brain
pax6 ref nk2.1 ref nk2.2 ref rx ref
Lineus ruber Nemertea Complex Broadly expressed with the exception of ventro-median domain this study Ventral brain, dorso-lateral domains this study Scattered expression in ventral, dorso-lateral and dorso-posterior domains this study Dorsal brain, ventro-lateral domains This study
Platynereis dumerilii Annelida Complex Paired lateral domains [47, 54] Ventro-median domain [47, 54] No expression in the brain [46] anterior brain [47]
Dimorphilus gyrociliatus Annelida Compact Paired lateral domains [48] Ventro-median and medio-lateral domains [48] No expression in the brain [48] N/A  
Capitella teleta Annelida Compact Paired lateral domains [53] nk2.1a: paired medio-lateral domains
nk2.1b: paired medio-lateral domains
[52] N/A   N/A  
Terebratalia transversa Brachiopoda Larval apical organ Paired dorso-lateral domains [78, 79] Ventral domain [51, 80] No expression in the apical organ [45] N/A  
Novocrania anomala Brachiopoda Larval apical organ Dorso-lateral domain [79] Ventral domain [80] No expression in the apical organ [45] N/A  
Phoronopsis harmeri Phoronida Larval apical organ No expression in the apical organ [81] No expression in the apical organ [82] N/A   N/A  
Schmidtea mediterranea Platyhelminthes Compact pax6A: broadly expressed throughout the brain
pax6B: lateral brain
[49] Ventral brain, dorso-median domains [50] No expression in the brain [83] N/A  
Epiphanes senta Rotifera Compact Paired lateral domains [45] nk2.1a: dorso-median domain
nk2.1b: median domain
nk2.1c: ventro-median domain
[45] Paired lateral domains [45] N/A