Fig. 8
From: Single-cell analysis of cell fate bifurcation in the chordate Ciona
The wide-hourglass model of cell state transitions. A A theoretical framework of a “narrow-hourglass” transcriptional response being primarily deployed through induction of a single tissue-specific master regulator. A’ A narrow-hourglass model of the Ciona notochord GRN focused on Brachyury. B The wide-hourglass transcriptional response includes many different TFs being upregulated alongside numerous putative effector genes at the time of cell fate induction via the same set of transcriptional inputs. B’ The wide-hourglass model of the Ciona notochord GRN presented in this paper. Dashed lines indicate transcriptional inputs broadly inferred from TFBS enrichment data, but these may not apply to each and every transcript upregulated in the early notochord